Levitra (Vardenafil) is a drug on Australian market that is utilized in the treatment of erectile dysfunction (ED). Along with sildenafil (Viagra) and tadalafil (Cialis), vardenafil (Levitra) is part of a family of medications that are called phosphodiesterase type 5 inhibitors or simply PDE5 inhibitors. Aside from minor differences in their duration of action and metabolism, these drugs work in the same manner to treat erectile dysfunction, which is defined as difficulty in achieving and maintaining an erection during sexual intercourse. Unlike tadalafil, which is also known as the “weekend pill” because it can work up to 48 hours, Levitra has a shorter yet more potent action, which is about 6 hours. PDE5 blockers are also sometimes used to treat a medical condition known as pulmonary hypertension, where they achieve symptom relief through the dilation of blood vessels, in a manner similar to the dilation achieved in the penis.
Vardenafil – Mechanism of action
Levitra’s mechanism of action consists of inhibition of an enzyme called PDE5. When sexual arousal occurs, the nerves that supply the penis release a signaling substance called nitric oxide (NO), which initiates a cascade of events culminating in an erection. Specifically, NO activates an enzyme that produces an active chemical compound called cGMP, which serves as a signaling molecule to initiate dilation of blood vessels in the penis and filling of cavernous chambers with blood. This is how an erection occurs after sufficient sexual stimulation. However, the duration of cGMP effects is short, especially in individuals who suffer from erectile dysfunction, because its action is terminated by PDE5, which destroys cGMP. The PDE5 enzyme is found specifically in the penis, but also in other organs like the lungs. Vardenafil works by inhibiting PDE5 thus preventing it from terminating the action of cGMP in the cavernous chambers of the penis, leading to a prolonged and stronger erection.
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Clinical safety and side effects
Levitra is an effective medication that is used to treat ED, which successfully passed clinical trials with few side effects. However, as most drugs, it has the potential to cause several mild and temporary side effects. If you experience nausea, headaches, pain in the abdominal region, light sensitivity or dizziness, don’t hesitate to contact your doctor who will decide whether these are side effects. Usually, there is no need to terminate treatment because side effects are mild and transient, if they ever occur. Levitra is one of the best treatments for erectile dysfunction, so if you have problems with erection, don’t hesitate to ask your doctor about how this remedy might improve your sexual life. It is highly recommended to undergo a thorough medical examination before initiating ED treatment with Levitra to prevent any interferences with other therapies or treatments.